Glossary
Softgel
Updated:
A softgel is a sealed gelatin or plant-based capsule filled with cannabinoid extract in carrier oil. Each one holds 1 fixed dose, with no taste and no dropper. Softgels are swallowed, so absorption follows the oral route and improves when taken with food.
Softgels are made by sealing a liquid fill inside a soft shell of gelatin or a plant-based substitute such as modified starch. For hemp products the fill is extract dissolved in MCT or another carrier oil, so a softgel is a tincture in a precise, pre-measured, flavorless form.
The appeal is consistency. Every capsule in a batch holds the same labeled amount, which removes dropper variation. The trade-off is that nothing is absorbed under the tongue; the whole dose goes through the stomach, intestine and liver.
That route is not as weak as its reputation. In a 2025 randomized crossover trial in healthy volunteers, a standard CBD isolate capsule delivered higher peak and total exposure than an enhanced liquid formulation when both were taken with food (J Cannabis Res 2025). Food is the lever: a systematic review reported about 5 times higher CBD exposure fed versus fasted (Millar 2018), and lipid fills raise exposure on their own (Zgair 2016).
Softgels take longer to act than inhaled or sublingual routes because the shell must dissolve first. The blister or bottle is the innermost container for federal total THC purposes.
Sources
- Randomized single-dose crossover comparative bioavailability study of two novel oral cannabidiol (CBD) formulations in healthy volunteers under fed conditions, compared to a standard CBD isolate capsule (J Cannabis Res, 2025) PubMed (accessed 2026-10-13)
- A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans (Front Pharmacol, 2018) PubMed (accessed 2026-10-13)
- Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines (Am J Transl Res, 2016) PubMed (accessed 2026-10-13)