Is 7-OH the same thing as kratom?

7-hydroxymitragynine is a minor alkaloid of Mitragyna speciosa. DEA's July 2026 notice stated that in its natural botanical form it "makes up less than two percent of the total alkaloid content or occurs in trace amount" (91 FR 40917). Mitragynine is the major alkaloid; on a leaf-derived extract report it appears in the tens of milligrams per serving and 7-OH appears as not detected or in the trace range.

Tablets, gummies and drink mixes in which 7-OH has been concentrated or produced by converting mitragynine, sold at 14 to 59 mg of 7-OH per tablet. FDA describes them as distinct from the plant and sent seven warning letters to their marketers in 2025 (FDA, Hiding in plain sight). A 2026 journal study of eight products sold as "kratom extract" found 22 to 75 mg/g of 7-OH against 2 to 6 mg/g of mitragynine, the reverse of the leaf profile (Kratom.news summary).

By concentration and ratio. The pending federal threshold controls 7-OH above 1 mg per gram or milliliter, or where mitragynine is less than 100 times the 7-OH by mass (91 FR 65370). Georgia, Virginia, Maryland, Mississippi, Florida and Kentucky draw their own lines in milligrams per serving, per gram or per container. Every one of those lines is a 7-OH line; none is a mitragynine line except Georgia's 150 mg per serving.

By the lab report. Every kratom product page prints the 7-OH result with its limit of quantitation; a product whose report shows 7-OH in the milligrams, or whose supplier markets it under that name, is not carried. See what this store does not sell.